D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID
D(+)-Tryptophan
CAS: 153-94-6
Molecular Formula: C11H12N2O2
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Names and Identifiers
| Name | D(+)-Tryptophan |
| Synonyms | D-TRP H-D-Trp-OH D-Tryptophan D-TRYPTOPHAN D-TRYPTOPHANE D(+)-TRYPTOPHAN D(+)-Tryptophan D-2-AMINO-3-INDOLEPROPIONIC ACID D-2-AMINO-3-INDOLYLPROPANOIC ACID D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID D-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID 3-(2,3-dihydro-1H-indol-3-yl)-D-alanine (R)-2-Amino-3-(3-indolyl)propionic acid |
| CAS | 153-94-6 |
| EINECS | 205-819-9 |
| InChI | InChI:1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15) |
| InChIKey | QIVBCDIJIAJPQS-SECBINFHSA-N |
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Physico-chemical Properties
| Molecular Formula | C11H12N2O2 |
| Molar Mass | 204.23 |
| Density | 1.1754 (rough estimate) |
| Melting Point | 282-285°C (dec.)(lit.) |
| Boling Point | 342.72°C (rough estimate) |
| Specific Rotation(α) | 31.5 º (c=1, H2O 24 ºC) |
| Flash Point | 195.4°C |
| Water Solubility | 11 g/L (20 ºC) |
| Solubility | Soluble in hot ethanol, alkaline solution and water, insoluble in chloroform, the aqueous solution is weakly acidic. |
| Vapor Presure | 4.27E-07mmHg at 25°C |
| Appearance | White or white-like crystalline powder |
| Color | White to slightly yellow |
| BRN | 86198 |
| pKa | 2.30±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Stable. Incompatible with oxidizing agents. |
| Refractive Index | 31 ° (C=1, H2O) |
| MDL | MFCD00005647 |
| Physical and Chemical Properties | melting point 282-285 ℃
|
| Use | Is an important nutritional agent, used in medicine as a control agent for the disease |
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | YN6129000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29339990 |
| Hazard Class | IRRITANT |
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Reference
| Reference Show more | 1. Gan Huiyu Huanglu. Preparation and Application of L-Proline Modified Gold Nanochannels [J]. Journal of Minjiang University 2019 40(02):101-105. 2. Xia, Yuanyuan, et al. "Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics." Journal of Food Composition and Analysis 62 (2017): 134-142.https:// doi.org/10.1016 3. [IF = 7.79] Ye Lu et al. "Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and D-amino acids." Nanoscale. 2020 Feb;12(8):4959-4967 4. [IF = 4.556] Dandan Zhao et al. "Physico-chemical properties and free amino acids profiles of six wolfberry cultivars in Zhongning." J Food Compos Anal. 2020 May;88:103460 5. [IF = 4.379] Feng Lin et al. "Chemical profile changes during pile fermentation of Qingzhuan tea effect inhibition of α-amylase and lipase." Sci Rep-Uk. 2020 Feb;10(1):1-10 6. [IF = 4.35] Xiaomei Dai et al. "1-Methylcyclopene Preserves the Quality of Chive (Allium schoenoprasum L.) by Enhancing Its Antioxidant Capacities and Organosulfur Profile during Storage." Foods. 2021 Aug;10(8):1792 7. [IF = 2.863] Qiang Wang et al. "Effects of turmeric on reducing heterocyclic aromatic amines in Chinese tradition braised meat products and the underlying mechanism." Food Sci Nutr.2021 Oct;9(10):5575-5582 8. [IF = 5.833] Yin Shi-Jun et al.Preparation of yolk-shell structure NH2-MIL-125 magnetic nanoparticles for the selective extraction of nucleotides.Microchim Acta. 2021 Dec;188(12):1-13 |
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Standard
Authoritative Data Verified Data
This product is L-2-amino -3(B-indole) propionic acid. Calculated as dried product, the content of C11H12N202 shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Trait
Authoritative Data Verified Data
- This product is white to yellowish crystal or crystalline powder; Odorless.
- This product is slightly soluble in water, very slightly soluble in ethanol, insoluble in chloroform, soluble in formic acid; Dissolved in sodium hydroxide test solution or dilute hydrochloric acid.
specific rotation
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 10mg per lml, and determine according to law (General rule 0621), the specific rotation was -30.0 ° to -32.5 °.
Last Update：2022-01-01 11:53:50
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Introduction
is an unnatural isomer of tryptophan
Last Update：2022-10-16 17:14:08
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Differential diagnosis
Authoritative Data Verified Data
- appropriate amounts of the product and the tryptophan reference product were dissolved in water and diluted to prepare a solution containing about 10mg per 1 ml as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 946).
Last Update：2022-01-01 11:53:51
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Exam
Authoritative Data Verified Data
acidity
take 0631g of this product, add 50ml of water to dissolve, and measure according to law (General Rule 5.4). The pH value should be 6.4.
transmittance of solution
take 0.5g of this product, add 2mol/L hydrochloric acid solution 20ml to dissolve, according to ultraviolet-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 95.0%.
chloride
take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.02% of standard sodium chloride solution, it should not be more concentrated ().
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().
ammonium salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard ammonium chloride solution, it shall not be deeper ().
other amino acids
take 0.30g of this product, put it in a 20ml measuring flask, add 1 mol/L hydrochloric acid solution 1 ml and water to dissolve, dilute with water to the scale, shake well, as a test solution; take 1 ml accurately, put it in a 200ml measuring flask, dilute it to scale with water, shake well, and use it as a control solution. Take 10mg of tryptophan control and tyrosine control, and put it in the same 25ml measuring flask, 1 ml of 1 mol/L hydrochloric acid solution and an appropriate amount of water were added to dissolve the solution. The solution was diluted to the scale with water and then shaken to form a suitable solution for the system. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 2 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-glacial acetic acid-water (3:1:1) to spread out, spread out, dry, spray with ninhydrin in acetone solution (1-50), heat at 80 °c until the * point appears, and view immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Iron Salt
take this product l. (Og) after burning and ashing, add hydrochloric acid (2ml) to the residue, dry it on a water bath, then add dilute hydrochloric acid (4ml), dissolve it in slight heat, add water (30ml) and ammonium persulfate (50mg), and check it according to law (General rule 0807), it should not be deeper (0.002%) than the control solution made of standard iron solution.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take 2.0g of this product, add 5ml of hydrochloric acid and 23ml of water to dissolve, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product, add human endotoxin test water, and heat to 80 ℃ to dissolve it, check according to law (General 1143), each lg of tryptophan containing endotoxin should be less than 50EU. (For injection)
Last Update：2022-01-01 11:53:52
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add anhydrous formic acid 3ml dissolved, add glacial acetic acid 50ml, according to the potential titration method (General rule 0701), with hydrochloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 20.42mg of C11H12N2O2.
Last Update：2022-01-01 11:53:52
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 11:53:53
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID - Storage
Authoritative Data Verified Data
light shielding, sealed, and stored in a cool place.
Last Update：2022-01-01 11:53:53
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View History
D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID
2-甲基-2-(5-甲基吡啶-2-丙氧基)丙酸
TacroliMus 8-Propyl Analog (USP)
4-(((2-氯嘧啶-5-基)氧基)甲基)哌啶-1-羧酸叔丁酯
N-[2-[(4-AMINO-3-METHYLPHENYL)ETHYLAMINO]ETHYL]METHANESULFONAMIDE SESQUISULFATE MONOHYDRATE
苄基二(2-羟乙基)甲基氢氧化铵
1-叔丁基二甲硅基咪唑[叔丁基二甲基硅化剂]
2-(3-硝基苯亚甲基)-3-氧代丁酸(2-甲氧基乙基)酯
Benzaldehyde, 4-[(2-methoxyethoxy)methoxy]-
(ALPHAS)-ALPHA-氨基环己烷丁酸
2-甲基-2-(5-甲基吡啶-2-丙氧基)丙酸
TacroliMus 8-Propyl Analog (USP)
4-(((2-氯嘧啶-5-基)氧基)甲基)哌啶-1-羧酸叔丁酯
N-[2-[(4-AMINO-3-METHYLPHENYL)ETHYLAMINO]ETHYL]METHANESULFONAMIDE SESQUISULFATE MONOHYDRATE
苄基二(2-羟乙基)甲基氢氧化铵
1-叔丁基二甲硅基咪唑[叔丁基二甲基硅化剂]
2-(3-硝基苯亚甲基)-3-氧代丁酸(2-甲氧基乙基)酯
Benzaldehyde, 4-[(2-methoxyethoxy)methoxy]-
(ALPHAS)-ALPHA-氨基环己烷丁酸